Activation of protective cell-mediated immune response in gastric mucosa during Cryptosporidium muris infection and re-infection in immunocompetent mice

Abstract

The differences between two isolates of Cryptosporidium muris (TS03 and CB03) in activation and development of cell-mediated immune response in stomach mucosa was observed during the primary infection and re-infection in immunocompetent mouse model. The development of the immune response was characterized by analysis of leukocyte infiltration into the gastric epithelium and cytokine production in ex vivo cultures of splenocytes