Modulace metabolických toků biosyntetickými drahami aminokyselin s větveným řetězcem u Corynebacterium glutamicum

Abstract

Metabolic fluxes in pathways of biosynthesis of branched-chain amino acids can be modulated by different changes in expression of genes of the desired pathway as well as those of competing pathways. Site-directed mutagenesis of promoters of the respective genes is a suitable tool to obtain desired changes in gene expression