Bee Wah Lee

Cahya D Satria

Christophe Lay

Doreen Leow

Ekawaty L Haksari

Gaik GaikChin Yap

Kaw Yan Chua

Kok Keong Chee

Lynette Pei-Chi Shek

Marion Aw

Pei-Ying Hong

Sumadiono

Yap, Gaik Chin

Yati Soenarto

Yudong Zhao

Springer

Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy

Gaik Chin Yap

null Sumadiono

Springer - Publisher Connector

Abstract
          
            Background
            Studies have suggested that demographic and lifestyle factors could shape the composition of fecal microbiota in early life. This study evaluated infant stool microbiota signatures in two Asian populations, Singapore (n = 42) and Indonesia (n = 32) with contrasting socioeconomic development, and examined the putative influences of demographic factors on these human fecal associated bacterial signatures.
          
          
            Results
            Longitudinal analysis showed associations of geographical origin with Clostridium leptum, Atopobium and Bifidobacterium groups. Mode of delivery had the largest effect on stool microbiota signatures influencing the abundance of four bacterial groups. Significantly higher abundance of bacterial members belonging to the Bacteroides-Prevotella, Bifidobacterium and Atopobium groups, but lower abundance of Lactobacilli-Enterococci group members, were observed in vaginal delivered compared to caesarean delivered infants. Demographic factors influencing the structure of infants stool microbiota during the first year of life included breastfeeding, age of weaning, sibship size and exposure to antibiotics.
          
          
            Conclusions
            Differences in stool microbiota signatures were observed in relation to various demographic factors. These features may confound studies relating to the association of the structure of fecal microbiota and the predisposition to human modern disease.
          </jats:sec

Crossref

BMC Microbiology

https://bmcmicrobiol.biomedcentral.com/track/pdf/10.1186/1471-2180-11-193?site=bmcmicrobiol.biomedcentral.com

Evaluation of stool microbiota signatures in two cohorts of Asian (Singapore and Indonesia) newborns at risk of atopy

Abstract

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Springer - Publisher Connector

Crossref

Springer - Publisher Connector