Synthetic biology: A novel approach for the construction of industrial microorganisms

Abstract

The recent achievement of synthesising a functioning bacterial chromosome marks a coming of age for engineering living organisms. In the future this should allow the construction of novel organisms to help solve the problems facing the human race, including health care, food, energy and environmental protection. In this minireview, the current state of the field is described and the role of synthetic biology in biotechnology in the short and medium term is discussed. It is particularly aimed at the needs of food technologists, nutritionists and other biotechnologists, who might not be aware of the potential significance of synthetic biology to the research and development in their fields. The potential of synthetic biology to produce interesting new polyketide compounds is discussed in detail.Croatian Science Foundation grant 09/5German Academic Exchange Service (DAAD)CNPq-TWAS (Conselho Nacional de Pesquisa do Brazil Third World Academy of Sciences, Brazil)FAPESP (Fundação de Apoio a Pesquisa do Estado de São Paulo, Brazil)FAPESP-King’s Colleg