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Hippocampal hypertrophy and sleep apnea: A role for the ischemic preconditioning?
Authors
A Cerasa
A Devisser
+80 more
AD Goldbart
AL Sica
AM Comi
B Fischl
CA Kushida
CR McDonald
D Gozal
D Gozal
D Gozal
D Gozal
DJ Durgan
DM Ferriero
Douglas R. Corfield
E Sforza
EA Webb
EH Gronenschild
EM Bålfors
EY Joo
EY Joo
F Torelli
FJ O'Donoghue
FJ O'Donoghue
G Hajak
G Pengas
GE Meadows
GG Haddad
GL Twigg
HH Ross
HK Yaggi
HM Bonnici
I Rosenzweig
I Rosenzweig
I Rosenzweig
Ivana Rosenzweig
J Nanduri
JD Schmahmann
JP Aggleton
JT McKenna
K Yaouhi
KB Walhovd
KJ Plessen
L Ayalon
L Eleore
L Lavie
LC Hoffmann
Lucio Annunziato
M Fotuhi
M Papadakis
Martin Glasser
Mary J. Morrell
Matthew J. Kempton
ME Jung
Milan Milosevic
MJ Morrell
MJ Morrell
MJ Morrell
N Canessa
N Canessa
PM Lledo
PM Macey
PM Macey
PP Newman
R Kumar
R Munoz
RJ Lichtenwalner
RX Aviles-Reyes
S Redline
Sandor Beniczky
Steven C. Williams
SV Schönwald
T Seki
TM Doring
U Dirnagl
VK Somers
William R. Crum
WS Tae
XH Zhu
Y Li
YW Tsai
YW Tsai
Publication date
1 January 2013
Publisher
Doi
Cite
View
on
PubMed
Abstract
The full impact of multisystem disease such as obstructive sleep apnoea (OSA) on regions of the central nervous system is debated, as the subsequent neurocognitive sequelae are unclear. Several preclinical studies suggest that its purported major culprits, intermittent hypoxia and sleep fragmentation, can differentially affect adult hippocampal neurogenesis. Although the prospective biphasic nature of chronic intermittent hypoxia in animal models of OSA has been acknowledged, so far the evidence for increased 'compensatory' neurogenesis in humans is uncertain. In a cross-sectional study of 32 patients with mixed severity OSA and 32 non-apnoeic matched controls inferential analysis showed bilateral enlargement of hippocampi in the OSA group. Conversely, a trend for smaller thalami in the OSA group was noted. Furthermore, aberrant connectivity between the hippocampus and the cerebellum in the OSA group was also suggested by the correlation analysis. The role for the ischemia/hypoxia preconditioning in the neuropathology of OSA is herein indicated, with possible further reaching clinical implications. © 2013 Rosenzweig et al
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