D'Cruz, D

Direskeneli, H

Hughes, G R V

Keser, G

Khamashta, M A

Miller, F

Targoff, I N

Objective. To determine the prevalence and associations of antiendothelial cell antibodies (AECA) in a well characterized cohort of patients with idiopathic inflammatory myopathies (IIM), Methods. Clinical characteristics, AECA, and myositis-specific autoantibodies were assessed by standard methods in 56 subjects with IIM. Results. AECA were found in 20/56 patients with IIM, were seen in all the major clinical and serologic IIM groups, and were found in 10/15 patients with interstitial lung disease (ILD) (chi squared 6.5, p &lt;0.01 with Yates' correction, relative risk 2.7, specificity 86% and sensitivity 50%). Antisynthetase antibodies, also associated with ILD as described (chi squared = 26.5, p &lt;0.001 with Yates' correction, relative risk 8.7, specificity 95%, sensitivity 77%), did not correlate with the presence of AECA, Conclusion. AECA appear to be present in all forms of IIM and are markers for no that are independent of anti-synthetase autoantibodies. AECA may be a useful serologic marker for ILD in IIM

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Antiendothelial cell antibodies in inflammatory myopathies: Distribution among clinical and serologic groups and association with interstitial lung disease

Antiendothelial cell antibodies in inflammatory myopathies: Distribution among clinical and serologic groups and association with interstitial lung disease

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