Björndahl, MA

Cao, R

Cao, Y

Clasper, S

Dissing, S

Galter, D

Garvin, S

Ikomi, F

Jackson, DG

Meister, B

Ohhashi, T

Religa, P

Tritsaris, K

Cancer Cell

Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors. Here we report that members of the PDGF family act as lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph nodes. These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis

Oxford University Research Archive

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.

AbstractCancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors. Here we report that members of the PDGF family act as lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph nodes. These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis

Cao, Renhai

Björndahl, Meit A.

Religa, Piotr

Clasper, Steve

Garvin, Stina

Galter, Dagmar

Meister, Björn

Ikomi, Fumitaka

Tritsaris, Katerina

Dissing, Steen

Ohhashi, Toshio

Jackson, David G.

Cao, Yihai

Elsevier - Publisher Connector 

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis 

Cao, R.

Bjorndahl, M.A.

Religa, P.

Clasper, S.

Garvin, S.

Galter, D.

Meister, B.

Ikomi, F.

Tritsaris, K.

Dissing, S.

Ohhashi, T.

Jackson, D.G.

Cao, Y.

Copenhagen University Research Information System

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

Oxford University Research Archive (ORA)

Giron, Vicente

Societat del Gran Teatre del Liceu

Diposit Digital de Documents de la UAB