Chapter 8 Immunocytochemical analysis of the workshop monoclonal antibody panel on small cell lung cancer, neuroblastoma and rhabdomyosarcoma cell lines

Abstract

We have studied the reactivity profile of the small cell lung cancer (SCLC) workshop monoclonal antibodies (Moabs) using SCLC, neuroblastoma, rhabdomyosarcoma and epithelial cell lines, applying the indirect immunoperoxidase technique on cytospin preparations. We conclude that Moabs belonging to clusters "1", "2" and "3" merit further immuno-cytochemical studies on a larger panel of SCLC cell lines. The relationship of expression of the antigens detected by these Moabs to tumour behaviour in vivo, remains to be explored. © 1988 Elsevier Science Publishers B.V. (Biomedical Division). All rights reserved