An, Qian

Birt, Matthew

Hafizi, Sassan

Pilkington, Geoffrey John

Vouri, Mikaella

English

Portsmouth University Research Portal (Pure)

Activation of the AXL kinase causes resistance to EGFRtargeted therapy in lung cancer. Nature Genetics.

An endogenous vitamin K-dependent mechanism regulates cell proliferation in the brain subventricular stem cell niche. Stem Cells.

Ashkenazi A and Settleman J. AXL inhibition sensitizes mesenchymal cancer cells to anti-mitotic drugs. Cancer Research.

Axl and growth arrest–specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with Glioblastoma Multiforme. Clinical Cancer Research.

Axl as a downstream effector of TGF-β1 via PI3K/ Akt-PAK1 signaling pathway promotes tumor invasion and chemoresistance in breast carcinoma. Tumor Biology.

AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Research.

Axl mediates tumor invasion and chemosensitivity through PI3K/Akt signaling pathway and is transcriptionally regulated by slug in breast carcinoma. IUBMB Life.

Biology of the TAM receptors. Cold Spring Harbor Perspectives in Biology.

Brain tumor cell line authentication, an efficient alternative to capillary electrophoresis by using a microfluidics-based system. Neuro-Oncology.

CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro-Oncology.

Current trends in targeted therapies for Glioblastoma Multiforme. Neurology Research International.

Differential TAM receptor– ligand–phospholipid interactions delimit differential TAM bioactivities. eLife.

Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.

Isolation and expression analysis of tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain. Molecular Brain Research.

Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis. Journal of Neuroinflammation.

Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. The Journal of Immunology.

Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology. Oncogene.

Merlo A and Hemmings BA. Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme. Oncogene.

NCBI GEO: archive for functional genomics data sets—update. Nucleic Acids Research.

NIH Image to ImageJ: 25 years of image analysis. Nature Methods.

Promotion of glioblastoma cell motility by Enhancer of Zeste Homolog 2 (EZH2) is mediated by AXL receptor kinase. Plos One.

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3–phosphatidylinositol 3-kinase–Akt pathway through its sex hormone-binding globulin-like Rregion. The Journal of Neuroscience.

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Research.

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New England Journal of Medicine.

Receptor Tyrosine Kinases, TYRO3, AXL and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.

Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases. Cytokine & Growth Factor Reviews.

TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system. Brain Research.

TAM receptors support neural stem cell survival, proliferation and neuronal differentiation. PLoS ONE.

Targeting Axl and Mer kinases in cancer. Molecular Cancer Therapeutics.

The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triplenegative breast cancer cells. Science Signaling.

Thorburn A and Graham DK. Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. Molecular Cancer Therapeutics.

Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach. Open Biology.

WHO classification of tumours of the central nervous system. Acta Neuropathologica.

Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

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http://eprints.port.ac.uk/id/document/42009

Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

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