We consider the high energy physics unfolding problem where the goal is to
estimate the spectrum of elementary particles given observations distorted by
the limited resolution of a particle detector. This important statistical
inverse problem arising in data analysis at the Large Hadron Collider at CERN
consists in estimating the intensity function of an indirectly observed Poisson
point process. Unfolding typically proceeds in two steps: one first produces a
regularized point estimate of the unknown intensity and then uses the
variability of this estimator to form frequentist confidence intervals that
quantify the uncertainty of the solution. In this paper, we propose forming the
point estimate using empirical Bayes estimation which enables a data-driven
choice of the regularization strength through marginal maximum likelihood
estimation. Observing that neither Bayesian credible intervals nor standard
bootstrap confidence intervals succeed in achieving good frequentist coverage
in this problem due to the inherent bias of the regularized point estimate, we
introduce an iteratively bias-corrected bootstrap technique for constructing
improved confidence intervals. We show using simulations that this enables us
to achieve nearly nominal frequentist coverage with only a modest increase in
interval length. The proposed methodology is applied to unfolding the Z boson
invariant mass spectrum as measured in the CMS experiment at the Large Hadron
Collider.Comment: Published at http://dx.doi.org/10.1214/15-AOAS857 in the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org). arXiv admin note:
substantial text overlap with arXiv:1401.827
