In this paper we study the equation w(4)=5w"(w2−w′)+5w(w′)2−w5+(λz+α)w+γ, which is one of the higher-order
Painlev\'e equations (i.e., equations in the polynomial class having the
Painlev\'e property). Like the classical Painlev\'e equations, this equation
admits a Hamiltonian formulation, B\"acklund transformations and families of
rational and special functions. We prove that this equation considered as a
Hamiltonian system with parameters γ/λ=3k, γ/λ=3k−1, k∈Z, is not integrable in Liouville sense by means of
rational first integrals. To do that we use the Ziglin-Morales-Ruiz-Ramis
approach. Then we study the integrability of the second and third members of
the PII-hierarchy. Again as in the previous case it
turns out that the normal variational equations are particular cases of the
generalized confluent hypergeometric equations whose differential Galois groups
are non-commutative and hence, they are obstructions to integrability