The Effect of the Extracts of Betel (Piper betel) Leaves on the Content of IL-1? as the Inflammatory Cytokine in Experimental Mice Using an Acute Wound Healing Modeling

Abstract

This study aims to determine the effect of ethyl acetate derived from the leaves extraction of betel (Piper betel) on the content of Interleukin-1? (IL-1?) in experimental mice using an acute wound healing modeling. The experimental design used randomized post test only group with 72 experimental mice which divided into 4 groups and each group consisted of 6 mice with three replications. The negative control group (I) was given vaseline after incision. The positive control group (II) was given bioplasenton. The third group (III) was topically given the extracts of betel leaves at 2% concentration and the fourth group (IV) was given the extracts of betel leaves at 3% concentration after incision respectively. The determination of IL-1? applied Immunoassay Quantikine Elisa (IQE). The quantitative analysis (statistical test) used complete randomized design using one-way anova with Spearma