Antić-Stanković, Jelena

Couladis, Maria

Lakušić, Branislava

Milenković, Marina

Pavlović, Milica

Slavkovska, Violeta

Arhiv za farmaciju

FarFar - Repository of the Faculty of Pharmacy, University of Belgrade

UDK 615 YU ISSN 004 1963ARHIVZA FARMACIJUc":As0|>|s|=ARMAc|_;u1's|<oqDRUSTVA  SRBIJESPECIJALNI BROJIV KONGRES FARMACEUTA SRBIIE. Sa mcdunarodnim u<':e§écmSavremena fzirmacija -unapredenje zdravlja i kvaliteta iivotaBEOGRAD, Sava Centar28. novcmbar - 2. deccmbar 2006 godinc5/2006ARH. FARM. Godina 56 Br. 5 Strana 639- 1021 BeogradAI"/2.f(1r/12 ZU06.'56.' 922 — 933 PP203SASTAV I ANTIMIKROBNA AKTIVNOST ETARSKOGULJA Chaerophyllum aureum L. (APIACEAE)B. Laku§ié', M. Pavl0vié', M. Couladisz, v. Slavkovskal,J. Antié Stankoviél, M. MilenkoviélI Farmaceutski fakultet, Univerzitet u Beogradu, Beograd, Srbija2 Department of Pharmacognosy and Chemistry of Natural Products,School of Pharmacy, University of Athens, GreeceRod Chaerophyllum je siroko rasprostranjen u Evropi, Aziji i Sevemoj Americi.U ori Evrope, zastupljen je sa 1 1, a u ori Srbije sa 6 vrsta (1). Predstavnik ovog roda,Chaerophyllum aureum L. je visegodisnja, zeljasta biljka. Cilj naseg rada bio jeispitivanje kolicine, sastava i antimikrobne aktivnosti etarskog ulja dobijenogdestilacijom vodenom parom iz herbe i plodova C. aureum.Biljni materijal je prikupljen sa dva lokaliteta na teritoriji Srbije: Suva planina,juni 2005 i Kopaonik, avgust 2005.Koliéina etarskog ulja je od 0.15 % (v/m) (herba) do 0.3 % (v/m) (plodovi). Usvim etarskim uljima dominantni su monoterpenski ugljovodonici (od 50.8 do 81.8 %).Kao glavne komponente su odredene: sabinen (od 18.5 do 31.6 %), p-cimen (od 7.9 do25.4 %) i limonen (od 1.9 do 10.9 %).Antimikrobna aktivnost testirana je na sest sojeva bakterija i dva soja Candidaalbicans, koristeci agar dl.lZlOLl metodu (2). Najbolja aktivnost ispitivanih etarskihulja ispoljena je na Staphylococcus epiderr51idis‘;,ATCC 12228, Micrococcus luteusATCC 10240 iStap/iylococcus aureus ATCC 2592/3,.>.Literatura: Z1. Nikolié,V. (1973): Chaerophyllum L. In: Josi=fovié,M.(ed.) Flora SR Srbije, V,SANU, Beograd; 32. Hili P., Evans C.S., Veness R.G., (1997). Antimicrobial action of essential oils:the effect of dimethylsulphoxide on the activity of cinnamonoil.Letters in Applied Microbiology 24, 269-275. A,.<+922/’1,.,. t.st .,_¥z‘ I"“- ..'8.a?'lial ~“%-7.. ‘»._,.FLJCOMPOSITION AND ANTIMICROBIAL ACTIVITY OFChaerophyllum aureum L. (APIACEAE) ESSENTIAL OIL- v-I Ic - r ' 2B. Lakusic , M. Pavlovic , M. CouladisJ. Antlc Stankovlc , M. Milenkovicl Faculty of Pharmacy, University of Belgrade, Republic of Serbia2 Department of Pharmacognosy and Chemistry of Natural Products,School of Phannacy, University of Athens, GreeceGenus Chaerophyllum is widespread in Europe, Asia and North America. In theora of Europe l l species occur, while in the ora of Serbia 6 species are present (l).One representative ofthis genus is Chaerophyllum aureum L., a perennial herb.The aim of our work was to investigate chemical composition and antimicrobialactivity of essential oil obtained by hydrodistillation from aerial parts and fruits of C.aureum.Plant material was collected from two localities, Suva planina in June 2005 andKopaonik in August 2005. The essential oil was isolated from aerial parts and fromfruits separately.The oil content was O.l5% (v/w) in aerial parts and 0.3 % (v/w) in fruits. In allsamples, the most dominant were monoterpene hydrocarbons (50.8 -81.8 %). The maincompounds were found to be sabinene (18.5-31.6 %), p-cymene (7.9-25.4 %) andlimonene (1.9-l0.9 %).The antimicrobial activity was tested on six bacterial strains and twostrains of Candida albicans, using agar diffusion method (2). The best activity oftestedessential oils was detected against Staphylococcus epidermidis ATCC /2228,/l/licrococcus luteus A TCC /0240 and Staphylococcus aureus A TCC 25923.923..~...-._. ,_.__..__.___.=l

Sastav i antimikrobna aktivnost etarskog ulja Chaerophyllum aureum L. (Apiaceae)

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Sastav i antimikrobna aktivnost etarskog ulja Chaerophyllum aureum L. (Apiaceae)

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