The study aims at introducing the cross-domain employability of Electronic Business (E-Business) that the printing industry professionals should have in Taiwan. The pilot study aims at confirming and developing a questionnaire based on indicator of employability on E-Business in Printing Industry. Secondly, designing Analytical Hierarchy Process (AHP) questionnaire and builds its weight. The study presents the cross-domain employability indicators related to E-Business. The contribution can benefit the printing industry when recruiting human resources, and to serve as reference for the printing related departments in higher education