Collaborative Networks represent organizational forms that became omnipresent in today’s way of making business. Such organizational forms are often established in order to satisfy a complex customer need, which one company could not satisfy on its own. This means that the participating companies are to a certain degree dependent on each other. Managing inter-firm relationships by means of inter-organizational interdependencies represents an important Business-IT Alignment issue. In this paper, we present the Dependency-based Alignment Framework, which represents a conceptual approach for managing changes in Collaborative Networks from a holistic perspective. A detailed and methodologically well-founded approach in the definition and design of our framework is accompanied by a detailed investigation of relevant properties of this design artifact. To demonstrate the applicability of our framework in practice, we introduce a case study, which uses Semantic Media Wiki and the SPARQL query language. Finally, we evaluate our results in an argumentative and deductively descriptive way
