New competitive challenges have forced Small-Medium Enterprises (SMEs) to re-examine their internal environment in order to improve competitive advantage. IT investments can improve firm performance in a way that it would be in “alignment” with business strategy. The purpose of this paper is to analyze the contemporary impact of IT and business strategy on business performance, incorporating all these constructs into a model that is tested using Multivariate Regression Analysis. Data were collected from IS executives in 160 Greek SMEs. The results of this survey show that Strategy conception and formulation have a significant impact on business performanc