We present ontological meta-analysis and synthesis as a method for reviewing, mapping, and visualizing the research literature in a domain cumulatively, logically, systematically, and systemically. The method will highlight the domain’s bright spots which are heavily emphasized, the light spots which are lightly emphasized, the blank spots which are not emphasized, and the blind spots which have been overlooked. It will highlight the biases and asymmetries in the domain’s research; the research can then be realigned to make it stronger and more effective. We illustrate the method using the emerging domain of Public Health Informatics (PHI). We present an ontological framework for the domain, map the literature onto the framework, and highlight its bright, light, and blank/blind spots. We conclude with a discussion of how (a) the results can be used to realign PHI research, and (b) the method can be used in other information systems domains