Optimal Spatial Requirements for the Location of Basic Residues in Peptide Substrates for the Cyclic Amp Dependent Protein Kinase

Abstract

The specificity of the [bovine muscle] cyclic[c]AMP-dependent protein kinase was examined using 2 series of dodecapeptides as substrates. One series consisted of peptides of the general sequence (gly)x-Arg-Arg-(Gly)y-Ala-Ser-Leu-Gly in which x + y = 6