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Targeting the master regulator mTOR: A new approach to prevent the neurological of consequences of parasitic infections?
Authors
C Burke
V Combes
+7 more
S Donnelly
WM Huston
M Johnson
M Labbate
B O'Brien
B Saunders
N Tiberti
Publication date
1 November 2017
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
© 2017 The Author(s). A systematic analysis of 240 causes of death in 2013 revealed that parasitic diseases were responsible for more than one million deaths. The vast majority of these fatalities resulted from protozoan infections presenting with neurological sequelae. In the absence of a vaccine, development of effective therapies is essential to improving global public health. In 2015, an intriguing strategy to prevent cerebral malaria was proposed by Gordon et al. 2015 mBio, 6:e00625. Their study suggested that inhibition of the mammalian target of rapamycin prevented experimental cerebral malaria by blocking the damage to the blood brain barrier and stopping the accumulation of parasitized red blood cells and T cells in the brain. Here, we hypothesize that the same therapeutic strategy could be adopted for other protozoan infections with a brain tropism, to prevent cerebral parasitosis by limiting pathogen replication and preventing immune mediated destruction of brain tissue
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OPUS - University of Technology Sydney
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Last time updated on 18/10/2019
Directory of Open Access Journals
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Last time updated on 30/11/2017