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research
Coexisting large and small vessel disease in patients with ischemic stroke of undetermined cause
Authors
Anastasios Chatzikonstantinou
Christian Fink
+4 more
Michael G. Hennerici
Radko Krissak
A. Schaefer
Stefan O. Schönberg
Publication date
1 January 2012
Publisher
S. Karger AG
Doi
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Abstract
Background and Purpose: Large artery atherosclerosis (LAA) and small vessel disease (SVD) share common risk factors for stroke. We aimed at investigating the association of SVD with cerebral LAA as well as with atherosclerosis in patients with stroke likely to originate from aortic plaques. Methods: We investigated 71 consecutive patients (48 men, mean age 64.2 +/- 13 years) with ischemic stroke of undetermined cause according to the ASCO classification, who received ECG-triggered CT angiography for best available atherosclerotic plaque detection in the aorta. Results: Aortic atherosclerotic plaques were detected in 54 patients (76.1%). The presence of SVD significantly correlated with the presence of aortic plaques (p < 0.001), as well as LAA (p < 0.001) and risk factors such as arterial hypertension (p = 0.032) and diabetes mellitus (p = 0.017). Conclusions: Aortic plaques are common in patients with stroke of undetermined cause. If so, SVD and LAA are often coexisting, which demonstrates the close link of macro- and microangiopathy, at least in cases of severe risk factors of atherosclerosis. Copyright © 2012 S. Karger AG, Base
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info:doi/10.1159%2F000339945
Last time updated on 12/01/2021
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Last time updated on 06/05/2016