Includes abstract.Includes bibliographical references.The defibrillation studies were performed in a porcine model given its resemblance to the human heart and its resilience to repeated ventricular fibrillation inductions (VF) and defibrillations. A novel sequential preshock waveform was assessed in a prototype serial capacitance device. Single and multi-electrode defibrillation vectors were evaluated in intra-cardiac, subcutaneous (SQ), and intra-pericardial configurations. The burden of ITS and the factors improving detection were assessed. Anti-tachycardia pacing was used to evaluate therapies in this patient cohort. The diagnostic utility of the post pacing interval (PPI) after failed ATP episodes was then investigated to help discriminate between atrial fibrillation/tachycardia (AF/AT) and VT
