There has been lately significant progress in the design of clinically assistive technologies for physiological and emotional wellbeing, driven by developments in Human Computer Interaction, Virtual Reality systems for rehabilitation and social interaction and Rehabilitation Robotics. The clinical, task-driven nature of such systems though often affects negatively the user acceptance of technology, resulting in lesser interactions with the user. At the same time, interactive environments which are not constructed for strictly medical applications, can also instigate interaction dialogues which generate physiological and emotional benefits for the user, while also incorporating a more playful dimension. As there is currently lack of communication channels between Clinically Assistive technologies and Socially Interactive Design Systems, the chapter attempts to merge these domains by identifying parameters related to physiological and emotional wellbeing that could inform the design of interactive systems for health and wellbeing at variable scales. These parameters are presented as a set of guidelines for Interaction design for healthcare and wellbeing, and the chapter elaborates on their practical application through three case studies: RoboZoo, Textrinium and Reflectego. All the presented case studies operate as public indoor or outdoor installations and have been tested in different contextual conditions, in Netherlands, Spain and France
