Breakspear, M

Rodrigues, S

Terry, JR

English

In this Letter, the genesis of spike-wave activity—a hallmark of many generalized epileptic seizures—is investigated in a reduced mean-field model of human neural activity. Drawing upon brain modelling and dynamical systems theory, we demonstrate that the thalamic circuitry of the system is crucial for the generation of these abnormal rhythms, observing that the combination of inhibition from reticular nuclei and excitation from the cortical signal, interplay to generate the spike-wave oscillation. The mechanism revealed provides an explanation of why approaches based on linear stability and Heaviside approximations to the activation function have failed to explain the phenomena of spike-wave behaviour in mean-field models. A mathematical understanding of this transition is a crucial step towards relating spiking network models and mean-field approaches to human brain modelling

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On the genesis of spike-wave oscillations in a mean-field model of human thalamic and corticothalamic dynamics

Rodrigues, S.

Terry, J.R.

Breakspear, M.

University of Birmingham Research Portal

On the genesis of spike-wave oscillations in a mean-field model of human thalamic and corticothalamic dynamics

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