A Venkateswaran

Alberto Davalos

AO Odegaard

AS Greenberg

AV Khera

BA Janowski

C Zetina Moguel

CD Mathers

DE Kleiner

DJ Gordon

DP Mertz

ER Mojica

FR Van der Leij

G Grant

George Grant

GJ Miller

H Komano

H Leontowicz

HA Tyroler

HH Liu

Hirian Alonso Moshe Barrera-Perez

I Hawa

J Ayo

J Folch

J Lin

J Wen

JC Cohen

JC Yoon

JD Horton

Jean-Marc A Lobaccaro

JJ Repa

Jorge Montero

Jorge Rubio-Piña

JR Schultz

JW Heinecke

JY Chiang

K Liu

KJ Livak

L Olivera

Leticia Olivera-Castillo

M Yahyavi

MC Damiani

MD Säemann

ME Rodríguez

MF Lopes-Virella

Miguel Angel Olvera-Novoa

N Hasegawa

N Torres

NE Miller

Nina Valadez-Gonzalez

P Araujo

P Lefebvre

Pablo Acereto-Escoffie

RG Herrmann

RK Semple

Roche Diagnostics

Rossanna Rodriguez-Canul

RR Sokal

S Acton

S Najwa

T Park

T Rajamohan

T Sugawara

VL Roger

Víctor Ceja-Moreno

X Duan

X Hu

XQ Hu

Y Zhong

Yasser Chim-Chi

Z Hossain

PLoS ONE

English

PubMed

Crossref

Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats

<div>Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth performance and body lipid profile in young rats were analyzed. Sea cucumber body wall was either lyophilized, cooked (100 °C, 1 h in water) and lyophilized, or oven-dried (70 °C for 12 h). It was then ground and incorporated into cholesterol-containing diets. I. badionotus meals supported growth and improved lipid profile in rats. In particular, serum cholesterol, low density lipoproteins, triglycerides concentration and atherogenic index values were greatly reduced by some I. badionotus containing diets. Liver total lipids, triglycerides and cholesterol were also reduced. Cooking or heat-treatment of the meals lowered but did not abolish their hypolipidemic potency. Gene expression analysis of several key genes involved in cholesterol and lipid metabolism in liver showed that diets containing I. badionotus repressed the induction of key genes associated with dyslipidemia exerted by cholesterol supplementation. Consumption of I. badionotus from the Yucatan Peninsula is beneficial for dyslipidemia, although biological effect is clearly dependent on preparation method. </div

Leticia Olivera-Castillo (486797)

Alberto Davalos (223939)

George Grant (270689)

Nina Valadez-Gonzalez (486798)

Jorge Montero (486799)

Hirian Alonso Moshe Barrera-Perez (486800)

Yasser Chim-Chi (486801)

Miguel Angel Olvera-Novoa (486802)

Víctor Ceja-Moreno (486803)

Pablo Acereto-Escoffie (486804)

Jorge Rubio-Piña (486805)

Rossanna Rodriguez-Canul (486806)

The Francis Crick Institute

Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats

Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth performance and body lipid profile in young rats were analyzed. Sea cucumber body wall was either lyophilized, cooked (100 °C, 1 h in water) and lyophilized, or oven-dried (70 °C for 12 h). It was then ground and incorporated into cholesterol-containing diets. I. badionotus meals supported growth and improved lipid profile in rats. In particular, serum cholesterol, low density lipoproteins, triglycerides concentration and atherogenic index values were greatly reduced by some I. badionotus containing diets. Liver total lipids, triglycerides and cholesterol were also reduced. Cooking or heat-treatment of the meals lowered but did not abolish their hypolipidemic potency. Gene expression analysis of several key genes involved in cholesterol and lipid metabolism in liver showed that diets containing I. badionotus repressed the induction of key genes associated with dyslipidemia exerted by cholesterol supplementation. Consumption of I. badionotus from the Yucatan Peninsula is beneficial for dyslipidemia, although biological effect is clearly dependent on preparation method

Directory of Open Access Journals

Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats.

Olivera-Castillo, Leticia

Davalos, Alberto

Grant, George

Valadez-Gonzalez, Nina

Montero, Jorge

Barrera-Perez, Hirian Alonso Moshe

Chim-Chi, Yasser

Olvera-Novoa, Miguel Angel

Ceja-Moreno, Víctor

Acereto-Escoffie, Pablo

Rubio-Piña, Jorge

Rodriguez-Canul, Rossanna

Aberdeen University Research

Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats

http://dx.plos.org/10.1371/journal.pone.0079446

Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats

Abstract

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Directory of Open Access Journals

Aberdeen University Research