Andreatta, Matthew

Loudet, Olivier

Poormohammad Kiani, Seifollah

Robert, Thierry

Salt, David E

Simon, Matthieu

Trontin, Charlotte

PLoS Genetics

English

PubMed

<div><p>As sessile organisms, plants have to cope with diverse environmental constraints that may vary through time and space, eventually leading to changes in the phenotype of populations through fixation of adaptive genetic variation. To fully comprehend the mechanisms of evolution and make sense of the extensive genotypic diversity currently revealed by new sequencing technologies, we are challenged with identifying the molecular basis of such adaptive variation. Here, we have identified a new variant of a molybdenum (Mo) transporter, MOT1, which is causal for fitness changes under artificial conditions of both Mo-deficiency and Mo-toxicity and in which allelic variation among West-Asian populations is strictly correlated with the concentration of available Mo in native soils. In addition, this association is accompanied at different scales with patterns of polymorphisms that are not consistent with neutral evolution and show signs of diversifying selection. Resolving such a case of allelic heterogeneity helps explain species-wide phenotypic variation for Mo homeostasis and potentially reveals trade-off effects, a finding still rarely linked to fitness.</p> </div

Seifollah Poormohammad Kiani (151796)

Charlotte Trontin (151800)

Matthew Andreatta (151803)

Matthieu Simon (41148)

Thierry Robert (151808)

David E. Salt (88328)

Olivier Loudet (20290)

FigShare

Allelic Heterogeneity and Trade-Off Shape Natural Variation for Response to Soil Micronutrient

Aberdeen University Research

Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient

As sessile organisms, plants have to cope with diverse environmental constraints that may vary through time and space, eventually leading to changes in the phenotype of populations through fixation of adaptive genetic variation. To fully comprehend the mechanisms of evolution and make sense of the extensive genotypic diversity currently revealed by new sequencing technologies, we are challenged with identifying the molecular basis of such adaptive variation. Here, we have identified a new variant of a molybdenum (Mo) transporter, MOT1, which is causal for fitness changes under artificial conditions of both Mo-deficiency and Mo-toxicity and in which allelic variation among West-Asian populations is strictly correlated with the concentration of available Mo in native soils. In addition, this association is accompanied at different scales with patterns of polymorphisms that are not consistent with neutral evolution and show signs of diversifying selection. Resolving such a case of allelic heterogeneity helps explain species-wide phenotypic variation for Mo homeostasis and potentially reveals trade-off effects, a finding still rarely linked to fitness

Seifollah Poormohammad Kiani

Charlotte Trontin

Matthew Andreatta

Matthieu Simon

Thierry Robert

David E Salt

Olivier Loudet

Directory of Open Access Journals

Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.

David E. Salt

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Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient

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Aberdeen University Research

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