Institute of Electrical and Electronics Engineers (IEEE)
Doi
Abstract
Abstract—Tissue perfusion measurement during catheter-guided stroke treatment in the interventional suite is currently not possible. In this work, we present a novel approach that uses a C-arm angiography system capable of CT-like imaging (C-arm CT) for this purpose. With C-arm CT one reconstructed volume can be obtained every 4–6 s which makes it challenging to measure the flow of an injected contrast bolus. We have developed an interleaved scanning (IS) protocol that uses several scan sequences to increase temporal sampling. Using a dedicated 4-D reconstruction approach based on partial reconstruction interpolation (PRI) we can optimally process our data. We evaluated our combined approach (IS-PRI) with simu-lations and a study in 5 healthy pigs. In our simulations, the cerebral blood flow values (unit: ml/100g/min) were 60 (healthy tissue) and 20 (pathological tissue). For one scan sequence the values were estimated with standard deviations of 14.3 and 2.9, respectively. For two interleaved sequences the standard devia-tions decreased to 3.6 and 1.5, respectively. We used perfusion CT to validate the in vivo results. With two interleaved sequences we achieved promising correlations ranging from r=0.63 to r=0.94. The results suggest that C-arm CT tissue perfusion imaging is feasible with two interleaved scan sequences. Index Terms—Perfusion imaging, dynamic reconstruction, C-arm CT, stroke treatment. I
