<i>mar</i> Operon Involved in Multidrug Resistance of <i>Enterobacter aerogenes</i>

Abstract

ABSTRACT We determined the sequence of the entire marRAB operon in Enterobacter aerogenes . It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin. </jats:p