One-instanton predictions are obtained from certain non-hyperelliptic Seiberg-Witten curves derived from M-theory for N=2 supersymmetric gauge theories. We consider SU(N_1)\times SU(N_2) gauge theory with a hypermultiplet in the bifundamental representation together with hypermultiplets in the defining representations of SU(N_1) and SU(N_2). We also consider SU(N) gauge theory with a hypermultiplet in the symmetric or antisymmetric representation, together with hypermultiplets in the defining representation. The systematic perturbation expansion about a hyperelliptic curve together with the judicious use of an involution map for the curve of the product groups provide the principal tools of the calculations
