Aim The aim of this study was to evaluate the sealing ability of two bioceramic endodontic sealers when used in combination with three different obturation techniques. Materials and methods A sample of 100 recently extracted intact human single-rooted anterior teeth was included in the study. After the instrumentation phase, the teeth were randomly divided into five groups and filled with different techniques and materials. Group 1 (n=20) was filled using Thermafil® obturators (Dentsply/Maillefer) with BioRootTM RCS (Septodont); Group 2 (n=20) was filled using a single GP cone with BioRootTM RCS (Septodont) bioceramic sealer; Group 3 (n=20) was filled using warm vertical condensation with BioRootTM RCS (Septodont) bioceramic sealer; Group 4 (n=20) was filled using warm vertical condensation with CeraSeal (Meta Biomed) bioceramic sealer; Group 5 (n=20) was filled with carrier-based obturation (Thermafil®, Dentsply/Maillefer) with CeraSeal (Meta Biomed) bioceramic sealer. Apical leakage was evaluated and statistical analysis was applied (Bonferroni and ANOVA tests) with the significance level set at P <0.05. Results All groups showed a low amount of apical leakage, without statistically significant differences. Conclusions Under in vitro conditions, the two bioceramic endodontic sealers used in combination with the obturation techniques used, both warm and cold gutta-percha, can similarly seal the root apex
