Studies on Some 10-[2-(N,N-Disubstituted Thiocarbamoylthio)Acetyl]Phenothiazine Derivatives

Abstract

WOS: A1992KE40400005PubMed ID: 1288509Nineteen 10-[2-(NN-disubstituted thiocarbamolythio) acetyl]phenothiazine derivatives have been synthesized by the reaction of 10-chloroacetylphenothiazine with potassium salt of N,N-disubstituted dithiocarbamic acid derivatives. The structures of the compounds have been elucidated by UV, IR, H-1-NMR spectra and microanalysis. The anticholinergic activity of the compounds was determined by assessing the inhibition of acetylcholine using atropine sulfate as a control. Results are discussed in relation to the activity and structure of the synthesized compounds