Let E and F be Hilbert C∗-modules over a C∗-algebra \CAlg{A}. New
classes of (possibly unbounded) operators t:E→F are introduced and
investigated. Instead of the density of the domain \Def(t) we only assume
that t is essentially defined, that is, \Def(t)^\bot=\{0\}. Then t has a
well-defined adjoint. We call an essentially defined operator t graph regular
if its graph \Graph(t) is orthogonally complemented in E⊕F and
orthogonally closed if \Graph(t)^{\bot\bot}=\Graph(t). A theory of these
operators is developed. Various characterizations of graph regular operators
are given. A number of examples of graph regular operators are presented
(E=C0(X), a fraction algebra related to the Weyl algebra, Toeplitz algebra,
Heisenberg group). A new characterization of affiliated operators with a
C∗-algebra in terms of resolvents is given