We propose a general multiscale approach for the mechanical behavior of
three-dimensional networks of macromolecules undergoing strain-induced
unfolding. Starting from a (statistically based) energetic analysis of the
macromolecule unfolding strategy, we obtain a three-dimensional continuum model
with variable natural configuration and an energy function analytically deduced
from the microscale material parameters. The comparison with the experiments
shows the ability of the model to describe the complex behavior, with residual
stretches and unfolding effects, observed in different biological materials
