The mapping between biological genotypes and phenotypes is central to the
study of biological evolution. Here we introduce a rich, intuitive, and
biologically realistic genotype-phenotype (GP) map, that serves as a model of
self-assembling biological structures, such as protein complexes, and remains
computationally and analytically tractable. Our GP map arises naturally from
the self-assembly of polyomino structures on a 2D lattice and exhibits a number
of properties: redundancy (genotypes vastly outnumber phenotypes),
phenotype bias (genotypic redundancy varies greatly between
phenotypes), genotype component disconnectivity (phenotypes consist
of disconnected mutational networks) and shape space covering (most
phenotypes can be reached in a small number of mutations). We also show that
the mutational robustness of phenotypes scales very roughly logarithmically
with phenotype redundancy and is positively correlated with phenotypic
evolvability. Although our GP map describes the assembly of disconnected
objects, it shares many properties with other popular GP maps for connected
units, such as models for RNA secondary structure or the HP lattice model for
protein tertiary structure. The remarkable fact that these important properties
similarly emerge from such different models suggests the possibility that
universal features underlie a much wider class of biologically realistic GP
maps.Comment: 12 pages, 6 figure