Aiki Shota

KANBARA Takaki

Koizumi Take-aki

KUWABARA Junpei

Taketoshi Ayako

Journal of Organometallic Chemistry

Tsukuba Repository  (Tulips-R)

The catalytic activity of a cyclometalatedruthenium(III) complex for aerobic oxidativedehydrogenation of benzylamines著者 Aiki Shota, Taketoshi Ayako, Kuwabara Junpei,Koizumi Take-aki, Kanbara Takakijournal orpublication titleJournal of organometallic chemistryvolume 696number 6page range 1301-1304year 2011-03権利 (C) 2011 Elsevier B.V.NOTICE: this is the author’s version of awork that was accepted for publication inJournal of organometallic chemistry. Changesresulting from the publishing process, such as peer review, editing, corrections,structural formatting, and other quality control mechanisms may not be reflected inthis document. Changes may have been made to this work since it was submitted forpublication. A definitive version wassubsequently published in Journal of organometallicchemistry, Vol.696. Issue:6, Pages:1301-1304.doi:10.1016/j.jorganchem.2010.10.063URL http://hdl.handle.net/2241/113009doi: 10.1016/j.jorganchem.2010.10.0631  The catalytic activity of a cyclometalated ruthenium(III) complex for aerobic 1 oxidative dehydrogenation of benzylamines 2  3 Shota Aiki,a Ayako Taketoshi,a Junpei Kuwabara,a Take-aki Koizumi,b and Takaki Kanbaraa* 4  5 aTsukuba Research Center for Interdisciplinary Materials Science (TIMS), Graduate School of Pure 6 and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8573, Japan 7 Tel.: +8129-853-5066; Fax: +8129-853-4490; E-mail: kanbara@ims.tsukuba.ac.jp 8 bChemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, 9 Yokohama, 226-8503, Japan 10  11 ABSTRACT 12  The ruthenium(III) complex bearing benzo[h]quinoline as a cyclometalated ligand was synthesized 13 and characterized by ESI-MS, elemental analysis, cyclic voltammetry and crystallography. The 14 complex serves as an efficient catalyst for the aerobic oxidative dehydrogenation of benzylamines to 15 the corresponding benzonitriles under mild conditions. 16  17 Keywords: Cyclometalated compounds; Ruthenium(III); Dehydrogenation; Amine. 18  19 1. Introduction 20  Development of catalytic systems using molecular oxygen as an oxidant has attracted much 21 attention from the consideration of green chemistry [1]. In particular, the aerobic oxidation of 22 amines is a useful method to obtain nitriles which have a great utility in the synthesis of 23 pharmaceutical compounds and industrial materials [2]. We previously reported that the aerobic 24 oxidative dehydrogenation of imidazolines and benzylamines is catalyzed by a cyclometalated 25 ruthenium complex, [RuCl(ppy)(tpy)][PF6] (1a) (ppy = 2-phenylpyridine; tpy = 26 2,2':6',2''-terpyridine) [3]. In these reactions, the essential steps are the coordination of substrate 27 to the ruthenium center and the aerobic oxidation of the ruthenium center. Therefore, the key 28 feature of the catalyst 1a is to have a Cl ligand and a cyclometalated ligand. Since the Cl ligand 29 easily dissociates, a substrate can coordinate to the vacant position. The σ-donor character of the 30 cyclometalated ppy ligand lowers the redox potential, which enables the aerobic oxidation of the 31 ruthenium center. This concept is considered to differ from that of the common 32 ruthenium-catalyzed dehydrogenation reaction which includes the formation of ruthenium 33 hydride species [2a-g,4]. To investigate this aerobic dehydrogenation system, we focused on a 34 ruthenium(III) complex bearing benzo[h]quinoline (bhq) as a cyclometalated ligand, 35 [RuCl(bhq)(tpy)][PF6] (1b), which can be considered to satisfy the above molecular design. Bhq 36 is known to form readily cyclometalated transition metal complexes due to the stability of the 37 five-membered heterometallacycle [5]. The Ru(III) complex 1b has not been isolated, although 38 the preparation of the corresponding Ru(II) complex, [RuCl(bhq)(tpy)], was reported [6]. We 39 2  report herein preparation and characterization of 1b. The catalytic activity of 1b for the aerobic 1 oxidative dehydrogenation of benzylamines is also described.  2  3 2. Results and discussion  4 2.1. Synthesis of Ru(III) complex 1b 5 The cyclometalated ruthenium(III) complex, [RuCl(bhq)(tpy)][PF6] (1b), was prepared by 6 stirring [RuCl3(tpy)] and bhq in 2-methoxyethanol at 70 °C in the presence of AgPF6. After the 7 removal of AgCl precipitation and the anion exchange with NH4PF6, 1b was obtained as a green 8 solid in 31% yield (Scheme 1). The ESI-MS spectrum of 1b showed the parent peak at m/z = 548 9 as a monocation pattern.  10 Insert Scheme 1. 11  12 The structure of complex 1b was confirmed by X-ray analysis. The ORTEP drawing of 1b is 13 shown in Fig.1 with selected bond lengths. Since the Ru-Cl bond length of 1b (2.418(2) Å) is 14 slightly shorter than that of 1a (2.4431(13) Å) [7], it is considered that the trans influence of the 15 cyclometalated bhq ligand is smaller than that of ppy ligand.  16 Insert Fig. 1 17  18 Cyclic voltammetry was performed on a DMF solution of 1b with 0.1 M [nBu4N][PF6] as a 19 supporting electrolyte. Three reversible redox waves were observed at E1/2 = –0.16, –2.11, and 20 –2.31 V vs. Fc+/Fc. The former one is assigned to the Ru(III)/Ru(II) redox couple, and latter two 21 are based on the redox processes of terpyridine and benzo[h]quinoline, respectively (Fig. 2). The 22 redox potential of Ru(III)/(II) in 1b (E1/2 = +0.48 V vs. NHE) lies in a similar range observed for 23 1a (E1/2 = +0.46 V) [7], and is expected to be sufficiently low for the aerobic oxidation of the 24 ruthenium center. 25 Insert Fig. 2 26  27 2.2. Application to aerobic oxidative dehydrogenation 28  First, oxidative dehydrogenation of 4-methylbenzylamine (2a) using 1b as a catalyst was 29 carried out in methanol under reflux in air. The reaction was monitored by 1H NMR spectroscopy 30 using mesitylene as an internal standard. The desired 4-methylbenzonitrile (3a) was obtained in 31 good yield after 14 h (Table 1, entry 1). The reaction proceeded much faster using molecular 32 oxygen (1 atm), the same reaction under a nitrogen atmosphere gave only a trace amount of 33 product (entries 2 and 3). These results indicate that molecular oxygen participates as the oxidant 34 in the catalytic reaction. The addition of bases accelerated the reaction, K2CO3 and Cs2CO3 were 35 especially effective (entries 2, 4-7). It is considered that the base induces deprotonation of the NH 36 group of the coordinated substrate. The reaction proceeded even at room temperature; 3a was 37 obtained in 80% yield (entry 8). 38 3  Insert Table 1 1  2 Next, the catalytic activity of 1b for the aerobic oxidative dehydrogenation of various 3 benzylamines 2a-2g was investigated; the results are summarized in Table 2. The corresponding 4 benzonitriles 3a-3g were obtained in every case. When the substance has an electron-withdrawing 5 group, the overreaction forming by-products such as 4-trifluoromethylbenzamide caused a 6 decrease in the yield of the nitrile [8]. 7 Insert Table 2 8  9 To probe the reaction pathway, similar ruthenium complexes, [Ru(bhq)(bpy)2][PF6] 1c (bpy = 10 2,2’-bipyridine) and [RuCl(phen)(tpy)][PF6] 1d (phen = 1,10-phenanthroline), were employed. In 11 both cases, negligible catalytic activities were observed (Table 3, entries 1 and 2). The inactivity 12 of 1c shows the coordination of 2a to the metal center is indispensable. The inactivity of 1d 13 indicates that the redox potential of Ru(III)/Ru(II) (E1/2 = +1.02 V vs. NHE [9]) is not enough low 14 for the aerobic oxidation of the ruthenium center. These results show that the reaction is 15 facilitated by the coordination of substrate to the metal center and the control of the redox 16 potential at the metal center. Consequently, we conclude that the reaction pathway for 1b is the 17 same to 1a (Scheme B1, see Appendix B) [3,10]. However the reaction using 1b was slower than 18 that of 1a (Table 3, entries 3 and 4). This result is consistent with the data of X-ray analysis and 19 cyclic voltammetry; the cyclometalated complex with a longer Ru-Cl bond length and a lower 20 redox potential serves as a superior catalyst for this aerobic dehydrogenation system.  21 Insert Table 3 22  23 3. Conclusions 24 We have prepared a cyclometalated ruthenium(III) complex 1b whose structure was confirmed 25 by a single-crystal X-ray diffraction study. The complex 1b was found to be an effective catalyst 26 for the aerobic oxidative dehydrogenation of benzylamines. It was revealed that the catalytic 27 activity correlates with the Ru-Cl bond length and the redox potential. The method outlined in 28 this paper is expected to contribute to the design of catalysts for aerobic oxidative 29 dehydrogenation. Further studies including an investigation of the reaction mechanism are in 30 progress. 31  32 4. Experimental 33 4.1. General  34 2a, methanol-d4 (Acros), AgPF6, 2c, 2d, 2f, 2g, 1,8-diazabicyclo[5.4.0]undec-7-ene (Aldrich), 35 K2CO3, Na2CO3, Cs2CO3, 2-methoxyethanol (Kanto Chemical), benzo[h]quinoline, 2b, 2e, and 36 mesitylene (TCI) were commercially available and were used without any further purification. 37 Complexes [RuCl3(tpy)] [11], 1a [7], 1c [5e], and 1d [9] were prepared in accordance with the 38 4  previous literature methods. Column chromatography was carried out by using Aluminium oxide 1 90 active acidic (Merck). 2 Elemental analysis was carried out with a Perkin-Elmer 2400-CHN instrument. ESI-Mass 3 spectrum was recorded on an Applied Biosystems QStar Pulsar i spectrometer. Cyclic 4 voltammograms were recorded on a ALS/CH Instruments Electrochemical analyzer 1200A with 5 a PFCE carbon working electrode, a Pt wire counter electrode and a 0.10 M AgNO3/Ag reference 6 electrode in a DMF solution containing 0.10 M [nBu4N][PF6] as a supporting electrolyte at room 7 temperature. Fc+/Fc = +0.060 V vs. 0.10 M AgNO3/Ag, and +0.64 V vs. NHE. 1H NMR spectra 8 were measured on a JEOL EX-270, a JNM-ECS-400 and a Bruker AVANCE-400 NMR 9 spectrometers. 10  11 4.2. Synthesis of Ru(III) complex 1b 12 [RuCl3(tpy)] (200 mg, 0.45 mmol), bhq (163 mg, 0.91 mmol) and AgPF6 (184 mg, 0.73 mmol) 13 were dissolved in 2-methoxyethanol (55 mL) and stirred at 70 °C for 12 h. The solution was 14 cooled to −20 °C for 1 h and then filtered through Celite to remove the AgCl precipitate. The 15 filtrate was concentrated to ca. 1 mL. An aqueous NH4PF6 solution was added to the concentrate. 16 The resulting precipitate was filtered off and purified by column chromatography (grade III 17 alumina, acidic, toluene/acetonitrile = 2/1). The green band was collected and acetonitrile was 18 evaporated. The precipitate was collected by filtration to give 1b as a green solid (98 mg, 31%). 19 ESI-MS: m/z = 548{M-PF6}+. Anal. Calcd. for [RuCl(bhq)(tpy)][PF6]·2H2O 20 (C28H23ClF6N6O2PRu): C, 46.13; H, 3.18; N, 7.69. Found C, 46.31; H, 3.52; N, 7.44. 21  22 4.3. X-ray crystal structure determination 23 C29.5H22N4F6PClO0.5Ru, M = 722.01, monoclinic, space group C2/m (No. 12), a = 15.0252(8) Å, 24 b = 24.2483(12) Å, c = 16.4057(9) Å, β = 97.9443(16)°, V = 5919.8(5) Å3, T = 88(1) K, Z = 8, 25 Dcalcd = 1.620 g cm-3, µ = 7.412 cm-1, F(000) = 2888.00, crystal size 0.30×0.10×0.05 mm. 28552 26 reflections collected, 6900 unique (Rint = 0.175), R1(I > 2σ(I)) = 0.1089, R (All reflections) = 27 0.1952, wR2 (All reflections) = 0.3525, Single crystals of 1b were obtained by the slow diffusion 28 of hexane into its solution in acetone. Intensity data were collected on a Rigaku R-AXIS Rapid 29 diffractometer with Mo-Kα radiation. Crystals were mounted on a glass capillary tube. A full 30 matrix least-squares refinement was used for non-hydrogen atoms except for PF6− with 31 anisotropic thermal parameters method by SHELXL-97 program. Hydrogen atoms were refined 32 using the riding model. 33  34 4.4. Oxidative dehydrogenation of 4-methylbenzylamine (2a) to 4-methylbenzonitrile (3a) using 35 1b as a catalyst (Table 1, entry 2).  36 A mixture of 2a (19 µL, 0.15 mmol), ruthenium complex 1b (5.2 mg, 7.5 x 10-3 mmol), K2CO3 37 (21 mg, 0.15 mmol), and mesitylene (10 µL, 7.5 x 10-2 mmol) in CD3OD (1 mL) was stirred 38 5  under O2 (1 atm). After stirring under reflux for 1 h, the yield was determined by 1H NMR using 1 mesitylene as an internal standard (89%). The spectral data of the obtained 3a were identical to 2 the previous literature [12]. 3  4 Acknowledgements 5 The authors thank the Chemical Analysis Center of University of Tsukuba for the measurements of 6 X-ray analysis, elemental analysis and NMR spectra. 7  8 Appendix A. Supplementary material 9 A complete set of X-ray crystallographic structural data for complex 1b (CCDC no. 794566) is 10 available at the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ,UK 11 (fax: +44 1223 336 033; e-mail: deposit@ccdc.ac.uk) on request, quoting the deposition number. 12  13 Appendix B. Supplementary data 14 Supplementary data associated with this article can be found, in the online version, at doi: 15  16 References 17 [1] (a) T. Punniyamurthy, S. Velusamy, J. Iqbal, Chem. Rev. 105 (2005) 2329-2363; 18    (b) M.J. Schultz, M.S. Sigman, Tetrahedron 62 (2006) 8227-8241. 19 [2] (a) R. Tang, S.E. Diamond, N. Neary, F. Mares, J. C. S. Chem. Commun. (1978) 562; 20 (b) K. Mori, K. Yamaguchi, T. Mizugaki, K. Ebitani, K. Kaneda, Chem. Commun. (2001) 21 461-462; 22    (c) K. Yamaguchi, N. Mizuno, Angew. Chem. Int. Ed. 42 (2003) 1480-1483; 23    (d) K. Yamaguchi, N. Mizuno, Chem. Eur. J. 9 (2003) 4353-4361; 24    (e) M. Kotani, T. Koike, K. 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Oxidative dehydrogenation of 2a using 1b as a catalysta 3 NH2 Ru catalyst 1b (5 mol%)2a 3aCD3OD, refluxCN 4 Entry Conditions Time (h) Yield (%)b 1 K2CO3 Air 14 78 2 K2CO3 O2 1.5 89 3 K2CO3 N2 1.5 trace 4 − O2 1.5 10 5 Na2CO3 O2 1.5 23 6 Cs2CO3 O2 1.5 88 7 DBU O2 1.5 31 8c K2CO3 O2 24 80 aThe reaction was carried out in 1 mL CD3OD with 2a (0.15 mmol), 1b (7.5×10-3 mmol) and a base (0.15 mmol). 5 bDetermined by 1H NMR spectroscopy using mesitylene as an internal standard. 6 cThe reaction was performed at room temperature. 7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27  28 8   1 Table 2. Oxidative dehydrogenation of 2a-2g using 1b as a catalysta 2 R NH2CD3OD, under O2Ru catalyst 1b (5 mol%), K2CO3R C N2 3  3 Entry R  Temp. (°C) Time (h) Yield (%)b 1 p-MeC6H4 a reflux 1.5 89 2 m-MeC6H4 b reflux 1.5 76 3 o-MeC6H4 c reflux 1.5 83 4 p-MeOC6H4 d reflux 1.5 93 5 Ph e reflux 1.5 74 6 p-ClC6H4 f 30 24 72 7 p-F3CC6H4 g 30 24 41 aThe reaction was carried out in 1 mL CD3OD with 2 (0.15 mmol), 1b (7.5×10-3 mmol) and a base (0.15 mmol). 4 bDetermined by 1H NMR spectroscopy using mesitylene as an internal standard. 5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27  28  29 9   1 Table 3. Oxidative dehydrogenation of 2a using 1a-1d as a catalysta 2 NH2 Ru catalyst  (5 mol%), K2CO32a 3aCD3OD, reflux, under O2CN 3 Entry Ru catalyst Time (h) Yield (%)b 1 1c 1.5 trace 2  1d 1.5 0 3 c 1a 1 87 4 1b 1 77 aThe reaction was carried out in 1 mL CD3OD with 2a (0.15 mmol), Ru catalyst (7.5×10-3 mmol) and a base (0.15 4 mmol). 5 bDetermined by 1H NMR spectroscopy using mesitylene as an internal standard. 6 cThe data are originated from ref.[3b]. 7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32  33 10   1 RuNNNClClAgPF6N CH3OC2H4OH, 70 °C, 12 h1bRuNNNNClPF6+Cl 2  3  4  5 Scheme 1. Synthesis of Ru(III) complex 1b. 6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32 11   1  2  3  4  5  6 Fig. 1. ORTEP drawing of Ru complex 1b at 30% ellipsoidal level. Hydrogen atoms, PF6− anion and 7 solvated acetone molecules are omitted for simplicity. Selected bond lengths (Å): Ru(1)-C(1), 8 1.981(9); Ru(1)-N(1), 2.137(9); Ru(1)-N(2), 2.065(9); Ru(1)-N(3), 1.942(9); Ru(1)-N(4), 2.062(9); 9 Ru(1)-Cl(1), 2.418(2). 10  11  12  13  14  15  16  17  18  19  20  21  22  23 12   1 -3.0 -2.5 -2.0 -1.5 -1.0 -0.5 0.0 0.5 1.0-2.43-2.18-2.23-1.995 µA-0.29-0.04Potential / V vs. Fc+/Fc 2  3 Fig. 2. Cyclic voltammogram of 1b in DMF containing [nBu4N][PF6] (0.1 M). Sweep rate = 100 4 mV/s. 5  6 

The catalytic activity of a cyclometalated ruthenium(III) complex for aerobic oxidative dehydrogenation of benzylamines

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