BIOINFORMATICS APPLICATIONS NOTE PIANA: Protein Interactions and Network Analysis

Abstract

Summary: We present a software framework and tool called PIANA that facilitates working with protein interaction networks by 1) integrating data from multiple sources, 2) providing a library that handles graph-related tasks and 3) automating the analysis of proteinprotein interaction networks. PIANA can also be used as a standalone application to create protein interaction networks and perform tasks such as predicting protein interactions and helping to identify spots in a 2D electrophoresis gel. Availability: PIANA is under the GNU GPL. Source code, database and detailed documentation may be freely downloaded fro