Revisión sistemática del estado de la terapia genética en las enfermedades neurodegenerativas. Se analizan y comentan los resultados de los 32 artículos finalmente seleccionados.Las terapias dirigidas a un sólo gen tienen buenas perspectivas en un futuro cercano en patologías de origen monogenético mientras que cuando están involucrados más genes es más complejo y menos factible

García-González, Nerea

Gonçalves-Estella, Jesús

Gonçalves-Estella, Jesús M.

Gonçalves-Sánchez, Jaime

Gómez-Nieto, Ricardo

López, Dolores E.

International Journal of Molecular Sciences

English

Gonçalves Estella, Jesús María

Gestion del Repositorio Documental de la Universidad de Salamanca

Advances and Challenges in Gene Therapy for Neurodegenerative Diseases: A Systematic Review

This review explores recent advancements in gene therapy as a potential treatment for neurodegenerative diseases, focusing on intervention mechanisms, administration routes, and associated limitations. Following the PRISMA procedure guidelines, we systematically analyzed studies published since 2020 using the PICO framework to derive reliable conclusions. The efficacy of various gene therapies was evaluated for Parkinson&rsquo;s disease (n = 12), spinal muscular atrophy (n = 8), Huntington&rsquo;s disease (n = 3), Alzheimer&rsquo;s disease (n = 3), and amyotrophic lateral sclerosis (n = 6). For each condition, we assessed the therapeutic approach, curative or disease-modifying potential, delivery methods, advantages, drawbacks, and side effects. Results indicate that gene therapies targeting specific genes are particularly effective in monogenic disorders, with promising clinical outcomes expected in the near future. In contrast, in polygenic diseases, therapies primarily aim to promote cell survival. A major challenge remains: the translation of animal model success to human clinical application. Additionally, while intracerebral delivery methods enhance therapeutic efficacy, they are highly invasive. Despite these hurdles, gene therapy represents a promising frontier in the treatment of neurodegenerative diseases, underscoring the need for continued research to refine and personalize treatments for each condition

Advances and Challenges in Gene Therapy for Neurodegenerative Diseases: A Systematic Review

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Gestion del Repositorio Documental de la Universidad de Salamanca

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