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Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
Authors
B Firoozabadi
N Kashaninejad
+6 more
JG Lock
H Moghadas
K Moshksayan
NT Nguyen
MS Saidi
ME Warkiani
Publication date
1 January 2018
Publisher
'Elsevier BV'
Doi
Cite
Abstract
© 2018 Elsevier B.V. A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids provide similar metabolism, proliferation, and species concentration gradients to those found in-vivo. For instance, cancer cell spheroids have been demonstrated to mimic in-vivo tumor microenvironments, and are thus suitable for in-vitro drug screening. The first part of this paper discusses the latest microfluidic designs for spheroid formation and culture, comparing their strategies and efficacy. The most recent microfluidic techniques for spheroid formation utilize emulsion, microwells, U-shaped microstructures, or digital microfluidics. The engineering aspects underpinning spheroid formation in these microfluidic devices are therefore considered. In the second part of this paper, design considerations for microfluidic spheroid formation chips and microfluidic spheroid culture chips (μSFCs and μSCCs) are evaluated with regard to key parameters affecting spheroid formation, including shear stress, spheroid diameter, culture medium delivery and flow rate. This review is intended to benefit the microfluidics community by contributing to improved design and engineering of microfluidic chips capable of forming and/or culturing three-dimensional cell spheroids
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OPUS - University of Technology Sydney
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Last time updated on 18/10/2019
Griffith Research Online
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Last time updated on 28/11/2018