Purpose: eHealth might contribute to changes in roles and responsibilities of patients and healthcare professionals (HCPs), including the patient’s potential to enhance self-regulation. The aim of this study was to identify important aspects and experiences of self-regulation and factors that may support self-regulation in blended rehabilitation care. Materials and methods: Semi-structured interviews were conducted among HCPs and patients regarding perceptions and experiences with self-regulation in relation to a telerehabilitation portal. Thematic analysis was used to identify themes. Results: According to HCPs (n = 18), aspects of self-regulation are: an active role of patients, a facilitating role for HCPs, and collaboration. Patients and parents (n = 24) experienced self-regulation by: having an active role and having a voice. Aspects of eHealth that support self-regulation are: at home usage, flexible scheduling, easily accessible communication, using it as a reference work, using it to stimulate motivation, and adapting usage to different phases of treatment. Conclusion: Patients and HCPs agree that patients having an active role is important for experiencing self-regulation. A telerehabilitation portal that can be flexibly used at home, with a communication and log module, can support self-regulation. Optimising eHealth design to stimulate self-regulation, and measuring the impact of eHealth on self-regulation should be further studied.</p