Therapeutic Potential of 1,8-Cineole in Respiratory Diseases with a Focus on Asthma, Sinusitis, and Upper Respiratory Tract Infections: A Comprehensive Review

Abstract

IntroductionRespiratory diseases, such as chronic sinusitis, asthma, and URTIs, are among the leading global health burdens, affecting tens of millions of people every year. These conditions often involve chronic inflammation, impaired mucociliary function, and obstruction of the airways, leading to deteriorating respiratory health.  The natural compound 1,8-cineole is a monoterpene present in eucalyptus oil and has received attention in recent times as an alternative therapeutic agent for respiratory diseases. Its anti-inflammatory, antioxidant, mucolytic, bronchodilatory, antiviral, and antimicrobial effects may be beneficial in the management of these diseases. Clinical evidence has shown that 1,8-cineole provides symptom relief, improves lung function, and enhances quality of life, particularly in patients with COPD, asthma, and chronic sinusitis. Besides, due to its good safety profile and minimal side effects, it represents a very attractive adjunctive treatment option. MethodsThis review synthesizes both classic and contemporary research findings on the mechanisms of action, clinical efficacy, and safety profile of 1,8-cineole. A comprehensive literature search was conducted across peer-reviewed journals to provide a balanced and evidence-based overview. ResultsEvidence indicates that 1,8-cineole effectively modulates inflammatory pathways by inhibiting cytokine release and suppressing arachidonic acid metabolism. Clinical trials demonstrate its efficacy in reducing symptoms of chronic sinusitis, improving pulmonary function in asthma, and alleviating symptoms in URTIs. Safety data support its tolerability, with mild gastrointestinal discomfort reported in rare cases. Conclusion1,8-Cineole represents a promising alternative or adjunctive treatment for inflammatory respiratory conditions. Future research should focus on optimizing delivery methods and investigating its synergistic potential with existing therapies