Mol Pharmacol 67:1360–1368, 2005 Printed in U.S.A. EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information

Abstract

Transcriptional profiling via microarrays holds great promise for toxicant classification and hazard prediction. Unfortunately, the use of different microarray platforms, protocols, and informatics often hinders the meaningful comparison of transcriptional profiling data across laboratories. One solution to this problem is to provide a low-cost and centralized resource that enables researchers to share toxicogenomic data that has been generated on a common platform. In an effort to create such a resource, we developed a standardized set of microarray reagents and reproducible protocols to simplify the analysis of More than 80,000 chemicals are in commercial use in the United States. This number, plus the addition of approximately 2000 new chemicals each year, makes it impossible to properly assess the toxicity of each compound in a timely manne