Chan, John K.

Johnson, Caitlin R.

Lancaster, Jonathan T.

Monroe, Anne K.

English

George Washington University: Health Sciences Research Commons (HSRC)

Methods:Results: Conclusion:Background:Relationship between Chronic Disease and Opioid Use Disorder in the United States, NSDUH 2015-2019Jonathan T. Lancaster1, Caitlin R. Johnson2, Anne K. Monroe1, John K. Chan2• Univariate, Chi-Square, and multivariate analyses were run to determine different associations and effect modification.• Of the 67,180 participants included in this study, 98.4% of participants were suffering from at least one chronic disease.• Hepatitis (OR 4.70; 95% CI: 3.12, 7.07; p=<0.0001) showed the strongest positive association with opioid misuse, while HIV/AIDS (OR 1.77; 95% CI: 1.07, 2.93; p=0.03) and COPD (OR 1.27; 95% CI: 1.07, 1.50; p=0.06) were moderately associated. • Diabetes (OR 0.68; 95% CI: 0.53, 0.87; p=0.0028) displayed aninverse association.• The opioid epidemic has seen increasing mortality in recent years, with deaths compounded by the effects of the COVID-19 pandemic. • To better understand risk factors for the evolving epidemic, associations between chronic diseases and opioid use disorder (OUD) was investigated.• Hepatitis, HIV/AIDS, and COPD were associated with increased odds of OUD while diabetes was inversely associated with odds of OUD.• Income acted as an effect modifier in the associations between OUD and diabetes along with OUD and hepatitis B/C.• Individuals suffering from these chronic diseases should not automatically be withheld pain-relieving opioids due to their chronic disease status since OUD is a complex disease that cannot be solely predicted by one factor.• Future research is warranted to determine different specific factors among chronic diseases that lead to such varying associations with OUD.Results:DiabetesChronic Bronchitis/COPDCirrhosis of liverHepatitis B or CKidney DiseaseAsthmaHIV/AIDSHigh blood pressure CancerHeart Condition0 1 2 3 4 5 6 7 8DiabetesChronic Bronchitis/COPDCirrhosis of liverHepatitis B or CKidney DiseaseAsthmaHIV/AIDSHigh blood pressureCancerHeart ConditionODDS RATIOFigure 1: Adjusted Odds Ratios for Chronic Disease-Opioid Use AssociationReported Chronic Diseases Present in ParticipantsFigure 2: Opioid Use Status, Examined by Demographic and Clinical Characteristics*1George Washington University; 2California Pacific Medical Center Research Institute Contact: jtlanca@gwu.eduObjectives:• Aim 1: To evaluate the association between previous chronic disease diagnosis and OUD.• Aim 2: To examine income as an effect modifier on the association between OUD and chronic disease status.DatasetExposureOutcome• Opioid use and chronic disease data was collected from the National Survey on Drug Use and Health (NSDUH) from 2015 to 2019.• OUD was defined as self-reported opioid use in any way not directed by a healthcare provider in the past 12 months. • The exposure consisted of 10 dichotomous self-report chronic disease variables analyzed individually.0%10%20%30%40%50%60%70%80%90%100%MaleFemaleMarriedWidowedDivorced or separatedNever been marriedCoveredNot coveredUrbanRuralEmployed full timeEmployed part timeUnemployedOtherExcellentVery goodGoodFair/poorSuicidal thoughtsNo suicidal thoughtsDepressionNo depressionAlcohol depedenceNo alcohol dependenceWhiteBlackAI/AL/Multi RacialAsianHispanic<$10,000$10,000-$19,999$20,000-$29,999$30,000-$39,999$40,000-$49,999$50,000-$74,999>$75,000Sex Marriage Status HealthInsuranceSetting Work Status Health Status SuicidalthoughtsDepression AlcoholAbuseRace IncomeAxis TitleOpioud use disorder No opioid use disorder*All variables included in this figure were significant following Chi-Square Analysis.

Relationship between Chronic Disease and Opioid Use Disorder in the United States, NSDUH 2015-2019

https://hsrc.himmelfarb.gwu.edu/cgi/viewcontent.cgi?article=1305&context=gw_research_showcase

Relationship between Chronic Disease and Opioid Use Disorder in the United States, NSDUH 2015-2019

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