Mining Yeast Transcriptional Regulatory Modules from Factor DNA-Binding Sites and Gene Expression Data

Abstract

In eukaryotes, gene expression is controlled by various transcription factors that bind to the promoter regions. Transcription factors may act positively, negatively or not at all. Di#erent combinations of them may also activate or repress gene expression, and form regulatory networks of transcription. Uncovering such regulatory networks is a central challenge in genomic biology