Inter-visit intraocular pressure range: An alternative parameter for assessing intraocular pressure control in clinical trials

Abstract

pressure (IOP) range, which reflects extreme and potendocumented risk factor for disease progression in tially damaging IOP fluctuations, provides additional glaucoma patients information on IOP control compared to mean IOP. ● DESIGN: Post hoc analysis of Xalatan/Lumigan/Travatan study data, a masked-evaluator, randomized, parallelgroup comparison of 12-week efficacy of latanoprost, bimatoprost, and travoprost in open-angle glaucoma/ ocular hypertension patients. ● METHODS: Pretreatment inter-visit IOP range defined as highest IOP minus lowest IOP at screening, safety check, and baseline (six measurements); posttreatment inter-visit IOP range defined as highest IOP minus lowest IOP at weeks two, six, and 12 or early termination (nine measurements). Ranges dichotomized as “high” (>6 mm Hg) vs “low”<6( mm Hg)