Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. Mol Vis 2009

Abstract

Purpose: To determine whether the polymorphisms of calcitonin receptor-like receptor gene (CALCRL) are associated with primary angle closure glaucoma (PACG) in a southern Chinese population. Methods: A total of 207 individuals with acute and chronic PACG and 205 ethnically matched controls were recruited in the current study. A tag-single nucleotide polymorphism approach was used to investigate this gene. Alleles were determined by PCR restriction fragment length polymorphism. Results: The results show a nominal association between rs1157699 and acute PACG (uncorrected p=0.024 and 0.028 for alleles and genotypes, respectively). Haplotype Trs840617Crs6759535Trs1157699 frequency is significantly higher in acute PACG patients than in controls (corrected p=0.012), whereas haplotype Trs840617Crs6759535Crs1157699 frequency is significantly lower in acute PACG patients compared with controls (corrected p=0.02). However, no significant difference was detected between chronic PACG and CALCRL tag single nucleotide polymorphisms. Conclusions: The study suggests a possible role of CALCRL in the pathogenesis of acute PACG but not chronic PACG. A replication of this study with a larger sample size as well as on different populations will be helpful in confirming this finding. Glaucoma is the second leading cause of blindness worldwide, and 60 million people will have open angl