. This work was supported by grants from Ministerio de Ciencia e Innovación-Spain, Fundación “M. Botín,” the European Union (FP7 MicroEnviMet) and the NIH (grant DC008603 to Y.W. Lundberg). The Instituto Universitario de Oncología is supported by Obra Social Cajastur and Acción Transversal del Cáncer-RTICC. S. Cabrera is supported by a fellowship from CONACYT-México