http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73954 Characterization of Shear-Sensitive Genes in the Normal Rat Aorta Identifies Hand2 as a Major Flow-Responsive Transcription Factor

Abstract

Objective: Shear forces play a key role in the maintenance of vessel wall integrity. Current understanding regarding sheardependent gene expression is mainly based on in vitro or in vivo observations with experimentally deranged shear, hence reflecting acute molecular events in relation to flow. Our objective was to combine computational fluid dynamic (CFD