ACKNOWLEDGEMENTS

Abstract

Germany under the supervision of Prof. Dr. Gerhard Winter. First and foremost, I would like to express my deepest gratitude to my supervisor Prof. Dr. Gerhard Winter, who gave me the opportunity to join his research group and to work in the fascinating field of protein pharmaceuticals. I want to thank him for his outstanding professional and enthusiastic guidance throughout this study and all the valuable advices that always encouraged and inspired me. I very much appreciated the numerous opportunities to present my work on congresses all over the world and the realization of my research stay in Colorado. I want to thank Prof. Dr. Wolfgang Frieß for his continuous enthusiasm and interest in my work, the scientific input and advice over the last years and for kindly being co-referee of this thesis. I would like to thank both of you, Prof. Winter and Prof. Frieß for the great efforts to provide excellent technical equipment and a pleasant working climate that made the development of this thesis not just possible, but a fulfilling and exciting time. I want to thank Dr. Sandra Schulze for her supervision and great support during the first months of this work. She excellently introduced me in the numerous analytical techniques and provided dedicated guidance at any time. I am indebted to Dr. Julia Myschik, who took over the supervision and was great help during preparation and performance of the animal studies. Many thanks to my cooperation partners from the University of Colorado: Prof. Dr. Theodore W. Randolph, Prof. Dr. John F. Carpenter and Maliheh Shomali for the cooperation and scientific input and thank you for the warm welcome during my research stay. Abbott GmbH & Co. KG is gratefully acknowledged for scientific and financial support, providing materials and enabling the realization of animal studies in Ludwigshafen. I am deepl