3rd International Conference on New Trends in Chemistry -- APR 28-30, 2017 -- Helsinki, FINLANDCopolymeric drug carrier system, poly (maleic anhydrite-co-vinyl acetate) copolymer (MAVA) carrying acriflavine drug (AF) has been examined by Zeta Potential Analyzer to determine the stability and controlled drug release tests in water with different pHs and simulated body fluids. Zetasizer measurements such as zeta potential, mobility, and particle size of prepared copolymer, drug and copolymer-drug conjugate (MAVA-AF) were done. The activity of copolymer-drug conjugate in different pHs and simulated body fluids was checked via UV-VIS spectrophotometer as a function of time.Scientific Research Project Coordination Center of Yildiz Technical University, Turkey [2016-01-02-YL06]; Sciences Research Projects Foundation of Cumhuriyet University, (CUBAP) [F258]This work was supported by the Scientific Research Project Coordination Center of Yildiz Technical University, Turkey (Project no: 2016-01-02-YL06) and Sciences Research Projects Foundation of Cumhuriyet University, (CUBAP, Project No: F258)