Glashoff, Richard Helmuth

English

Cape Town University OpenUCT

Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients.

Anergic T cells act as suppressor cells in vitro and in vivo.

Antibacterial activity of human natural

Apoptotic pathways: The roads to ruin. Cell 94:695-698

b. Tuberculosis in adults. In: A century of tuberculosis.

Broad clonal heterogeneity of antigen-specific CD4+ T-cells localizing at the site of disease during tuberculosis.

CD14 receptor-mediated uptake of non-opsonised Mycobacterium tuberculosis by human microglia.

CD4+ cytolytic T cells can destroy autologous MHC-matched macrophages but fail to kill intracellular Mycobacterium bovis BCG. FEMS Imm un 01,

CD8+ T lymphocytes in intracellular microbial infections.

Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritis.

Death receptors: signaling and modulation.

Degradation of cell proteins and the generation of MHC class I-presented peptides.

Diagnostic procedures for pleural disease.

Differential induction of apoptosis by Fas-Fas Ligand interactions in human monocytes and macrophages.

directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity 8:451-460

Effects of mycobacteria on regulation of apoptosis in mononuclear phagocytes.

Establishmnet of . stable C8+ suppressor t cell clones and the analysis of their suppressive function.

gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes.

Granule-mediated cytotoxicity. In: Apoptosis: Biology and mechanisms. Results and problems in cell differentiation vo1.23. 77 102.

Human IL-10 is produced by both type-1 helper (Th1) and typ-2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

Identification, isolation and characterisation of a novel cytotoxin in murine cytolytic lymphocytes.

IL-12 augments antigen-dependent proliferation of activated T lymphocytes.

Induction of antigen-specific CD4+ HLA-DR restricted T lymphocytes as well as non-specific non-restricted killer cells by the recombinant mycobacterial 65kDa heat shock protein.

Induction of in vitro human macrophage anti Mycobacterium tuberculosis activity: requirement for IFN-y and primed lymphocytes.

Interaction of Mycobacterium tuberculosis~induced transforming growth factor beta 1 and interleukin-10.

Interleukin-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

Killing of Mycobacterium tuberculosis within human monocytes: activation by cytokines and calcitriol.

Kinetics of purified protein derivative (PPD) proliferation reflects underlying suppressor mechanisms revealed by limiting dilution analysis (LDA) in patients with extrapulmonary tuberculosis (TB).

Limiting dilution analysis of cells in the immune system.

Limiting dilution analysis of the cells of the immune system I.

Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.

Lymphocyte granule-mediated apoptosis; matters of viral mimicry and deadly proteases, Immunol. Today

Lysis of human macrophages by cytolytiC CD4+ T celis fails to affect survival of intracellular Mycobacterium bovis-bacille Cal mette-Guerin

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production.

Models of T cell anergy: is there a common molecular mechanism?

Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.

Mycobacterial growth and sensitivity to H20 2 killing in human monocytes in vitro.

Mycobacterium tuberculosis antigen specific human T-cell lines are cytolytic to autologous antigen pulsed macrophages.

Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis.

Perforin-induced pore formation.

Programmed cell death ofT cells signalled by the T cell receptor or the a3 domain. SCience 252: 1424-1426

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

Recombinant interleukin-2 limits the replication of Mycobacterium lepraemurium and Mycobacterium bovis BCG in mice.

Relationship of the manifestations of tuberculosis to CD4 cell counts in patients with human immunodeficiency virus infection.

Role of extracellular adenosine triphosphate in the cytotoxic T -lymphocyte-mediated lysis of antigen presenting cells.

Soluble antigen-primed inducer T cells activate antigen-specific suppressor t cells in the absence of antigen-pulsed accessory cells: phenotypic definition of suppressor-inducer and suppressor-effector cells.

Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen activated CD4 cells.

Suppression of immune responses by CD8 cells.

Suppressor cells and immunity.

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor-beta.

SuppressorT lymphocytes from lepromatous leprosy skin

T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection.

T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2.

The clonal basis of the immune response.

The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme mediated cytolytiC mechanisms.

The role of cytokines in the immune response to tuberculosis.

Toxoplasma gondii-induced immune suppression by human peripheral blood monocytes: role of gamma interferon.

Two CD95 (Apo-1/Fas) signalling pathways.

Characterisation of cytolytic CD4+ and suppresor CD8+ activity of T lymphocyte clones derived from tuberculous pleuritis

https://open.uct.ac.za/bitstream/11427/3390/1/thesis_hsf_2000_glashoff_r_h.pdf

Characterisation of cytolytic CD4+ and suppresor CD8+ activity of T lymphocyte clones derived from tuberculous pleuritis

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Cape Town University OpenUCT