In this contribution design thinking is taken as a transfer of design methods from product development to other domains. It is argued that the success of this transfer depends on the organisational context offered to design thinking in these other domains. We describe the application of design methods in product development and in two new domains by what we have called the IDER model, where D refers to design and I, E and R to the organisational context. Then we show that characteristics of the contexts in the new domains may determine the success of applying design thinking in these domains. Finally we focus on the transitions among design and the other contextual elements as another source that can ‘make or break’ the success of applying design thinking. We support our arguments with two cases of design thinking: social design and business-innovation design